^99mTc-labelled biphosphonates

Clinical Evaluation	Osteoblastic activity
Type of Imaging	Scintigraphy
Grade of Recommendation	B (generally recommended)
Level of Evidence	well-designed NM recommendations
Effective Dose	4.9 µSv/MBq
Bibliographic Reference	Noordin, S., Allana, S., Hilal, K., Nadeem, N., Lakdawala, R., Sadruddin, A., et al. Osteoid osteoma: Contemporary management. Orthop Rev (Pavia).... read more Noordin, S., Allana, S., Hilal, K., Nadeem, N., Lakdawala, R., Sadruddin, A., et al. Osteoid osteoma: Contemporary management. Orthop Rev (Pavia). 2018; https://doi.org/10.4081/or.2018.7496. Dookie, A. L., Joseph, R. M. Osteoid Osteoma. StatPearls. Treasure Island (FL)2021. - https://www.ncbi.nlm.nih.gov/books/NBK537279/ Sharma, P., Mukherjee, A., Karunanithi, S., Nadarajah, J., Gamanagatti, S., Khan, S. A., et al. 99mTc-Methylene diphosphonate SPECT/CT as the one-stop imaging modality for the diagnosis of osteoid osteoma. Nucl Med Commun. 2014; https://doi.org/10.1097/MNM.0000000000000134. read less

Clinical Evaluation
Osteoblastic activity
Type of Imaging
Scintigraphy
Grade of Recommendation
B (generally recommended)
Level of Evidence
well-designed NM recommendations
Effective Dose
4.9 µSv/MBq
Bibliographic Reference
Noordin, S., Allana, S., Hilal, K., Nadeem, N., Lakdawala, R., Sadruddin, A., et al. Osteoid osteoma: Contemporary management. Orthop Rev (Pavia).... read more Noordin, S., Allana, S., Hilal, K., Nadeem, N., Lakdawala, R., Sadruddin, A., et al. Osteoid osteoma: Contemporary management. Orthop Rev (Pavia). 2018; https://doi.org/10.4081/or.2018.7496. Dookie, A. L., Joseph, R. M. Osteoid Osteoma. StatPearls. Treasure Island (FL)2021. - https://www.ncbi.nlm.nih.gov/books/NBK537279/ Sharma, P., Mukherjee, A., Karunanithi, S., Nadarajah, J., Gamanagatti, S., Khan, S. A., et al. 99mTc-Methylene diphosphonate SPECT/CT as the one-stop imaging modality for the diagnosis of osteoid osteoma. Nucl Med Commun. 2014; https://doi.org/10.1097/MNM.0000000000000134. read less